What is IUI?
IUI, or intrauterine insemination, is a fertility treatment in which sperm are collected, washed, and concentrated before being inserted directly into the uterus. This bypasses the cervix and facilitates sperm transport toward the fallopian tubes, where fertilization occurs.
IUI may be performed:
- In a natural ovulatory cycle
- After mild ovarian stimulation with medication
- With partner or donor sperm
It is often considered before moving to more advanced treatments like IVF, depending on the cause of infertility.
Why is IUI Performed?
IUI is used to improve the chances of fertilization by enhancing sperm access to the egg. It may be recommended for couples with mild fertility challenges or specific conditions. Early intervention with IUI can also be helpful in cases of unknown or unexplained infertility.
IUI is Typically Recommended for:
- Cervical factor infertility (e.g. hostile cervical mucus)
- Vaginismus or other sexual dysfunction
- Mild ovulatory disorders
- Mild male factor infertility (e.g. low motility or count)
- Couples using donor sperm due to azoospermia or genetic conditions
- Single women
Who Can Benefit from IUI?
IUI is typically recommended for:
- Blocked or severely damaged fallopian tubes
- Severely diminished ovarian reserve (e.g. high day-3 FSH in young women)
- Severe male factor infertility
- Structural abnormalities of the uterus
- Advanced maternal age with low success prognosis
- A prior fallopian tube evaluation (e.g., Foam SonoHSG) is typically required before starting IUI to confirm tubal patency.
When Is IUI Not Recommended?
IUI May not be Suitable for Patients with:
- Blocked or severely damaged fallopian tubes
- Severely diminished ovarian reserve (e.g. high day-3 FSH in young women)
- Severe male factor infertility
- Structural abnormalities of the uterus
- Advanced maternal age with low success prognosis
A prior fallopian tube evaluation (e.g., Foam SonoHSG) is typically required before starting IUI to confirm tubal patency.
Step-by-Step: How IUI Works at Reproart
Initial Evaluation – Includes hormone testing, ultrasound, and tubal assessmen
Follicle Monitoring – Follicle growth and hormone levels are assessed using transvaginal ultrasound and blood tests
Ovulation Trigger – When the leading follicle reaches ~18–20 mm, an hCG trigger shot may be administered
Ovarian Stimulation (if needed) – Mild fertility medications are used to encourage egg development
Sperm Preparation – Partner or donor sperm is processed in the lab for motility and quality
Insemination Procedure – A fine catheter is used to place sperm into the uterus; the procedure is quick and painless
Success Rates
Success with IUI depends on age, diagnosis, ovarian reserve, and sperm quality.
Average pregnancy rates per cycle vary between 10–20%, with cumulative chances improving over 3–4 attempts. If IUI fails after several cycles, IVF may be recommended.
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Frequently Asked Questions (FAQs)
We know that fertility care often brings up many questions — and that every journey is different. Below you’ll find answers to some of the most common questions our patients ask.
Is IUI painful?
No. The insemination process is brief and typically causes little to no discomfort.
How long does the IUI process take?
Each cycle takes about 2–3 weeks, depending on ovulation timing and response to medication. The insemination itself takes just a few minutes.
What is the next step if IUI fails?
If pregnancy is not achieved after 3–4 IUI cycles, your reproductive endocrinologist may recommend transitioning to IVF for higher success rates.
Do I need bed rest after IUI?
No. There is no medical requirement for bed rest after the procedure. You can resume normal activities immediately.
Do I need to use medication with IUI?
Not always. Some patients undergo IUI in a natural cycle. However, mild stimulation can increase success rates in many cases.
Can I travel or work after the IUI procedure?
Yes. There are no restrictions on activity after IUI. You can return to your normal routine, including work and light travel, unless otherwise advised by your doctor.
